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Secular Trend in the Frequency of Pathologic GJB2 and GJB6 Mutations among the Deaf: Deaf Probands with One or Two Deaf Parents
|
Birth Cohorts |
||||
|---|---|---|---|---|
| Statistic | 1920–1940 | 1941–1960 | 1961–1980 | Total |
| Number of Subjects | 31 | 76 | 92 | 199 |
| Number of Genes | 62 | 152 | 184 | 398 |
| Number of Mutations | 31 | 80 | 101 | 212 |
| Frequency of Mutations (%) | 50 | 53 | 55 | 53 |
Linear-trend analysis: Z score 0.69, not significant.
