Figure 5.

Expression Divergence between Human, Chimpanzee and Macaque RFPL1,2,3 Genes in Brain

RFPL1,2,3 gene expressions were assessed in newborn and adult neocortex, cerebellum, and liver by microarray transcriptome studies in humans, chimpanzees, and macaques. Results are displayed as mean ± standard error (SEM). The following abbreviations are used: Cx, neocortex; Cb, cerebellum; Liv, liver; H, human; C, chimpanzee; and Ma, macaque. (A) shows intraspecies divergence in RFPL1,2,3 tissue expression. Cortical and cerebellar RFPL1,2,3 transcript levels were normalized to that of the liver. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001 for neocortex or cerebellum versus liver; ^#p < 0.05 and ^##p < 0.01 for neocortex versus cerebellum with one-way ANOVA followed by post hoc Tukey test. (B) shows interspecies divergence in cortical and cerebellar RFPL1,2,3 expression levels. hRFPL1,2,3 expressions were normalized to those in chimpanzee or macaque. ^∗p < 0.05 and ^∗∗∗p < 0.001 with Student's t test.