Table 1.

Comparison of body, heart, and lung weight in α^*_q52 and wild-type mice at 2, 4, and 10 weeks of age

	2 weeks		4 weeks			10 weeks
	WT, n = 33	α*q52, n = 33	WT, n = 5	α*q52, n = 7		WT, n = 18	α*q52, n = 30
Body weight (BW, g)	6.8  ± 1.4	6.5  ± 1.5	16.1  ± 2.4	15.6  ± 6.1		22.1  ± 1.6	22.0  ± 2.0
Atria
Weight (AW, mg)	3.6  ± 0.6	3.6  ± 0.6	7.8  ± 2.4	15.2  ± 5.3†	(LA)	3.7  ± 0.6	18.3  ± 14.7§
					(RA)	3.5  ± 0.6	9.0  ± 3.6§
AW/BW, mg/g	0.55  ± 0.07	0.57  ± 0.09	0.48  ± 0.08	1.00  ± 0.22§	(LA)	0.17  ± 0.03	0.84  ± 0.72§
					(RA)	0.16  ± 0.03	0.41  ± 0.18§
Ventricles
Weight (VW, mg)	34  ± 6	34  ± 7	65  ± 8	71  ± 17		85  ± 7	103  ± 17§
VW/BW, mg/g	5.00  ± 0.3	5.20  ± 0.3‡	4.05  ± 0.15	4.79  ± 0.98		3.88  ± 0.26	4.7  ± 0.8§
Lungs
Lung W/BW, mg/g	16.9  ± 3.7	17.4  ± 2.8	10.8  ± 2.0	10.0  ± 1.6		7.5  ± 0.9	9.7  ± 2.2§

For the 2-week time point, data were obtained from eight litters containing equal numbers of heterozygous and wild-type mice. At 4 and 10 weeks, only data for females are shown. At 10 weeks, data for left and right atria (LA and RA) are shown separately. Ten-week-old male α^*_q52 mice gave similar results compared with wild-type mice (data not shown). Values given are mean ± SD.  

^†P < 0.02;  

^‡P < 0.005; and  

^§P < 0.0005 (Student’s t-test) relative to age-matched wild type.