Abstract
Salmefamol is a new sympathomimetic drug with predominantly β2 actions. In a double-blind trial in a group of twenty-four patients with airway obstruction, we have compared the effect of 100 μg of salmefamol given by metered aerosol with that of a placebo aerosol. In the same patients we have also compared the aerosols with subcutaneous adrenaline and subcutaneous atropine, the sequence of treatments being determined by a latin square design.
At all times salmefamol had a significantly greater bronchodilator effect than the placebo. Although the effects of atropine and adrenaline were greater at the earlier times of measurement, that of salmefamol was greater at 4 hr.
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Selected References
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- Choo-Kang Y. F., Simpson W. T., Grant I. W. Controlled comparison of the bronchodilator effects of three beta-adrenergic stimulant drugs administered by inhalation to patients with asthma. Br Med J. 1969 May 3;2(5652):287–289. doi: 10.1136/bmj.2.5652.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crompton G. K. A comparison of responses to bronchodilator drugs in chronic bronchitis and chronic asthma. Thorax. 1968 Jan;23(1):46–55. doi: 10.1136/thx.23.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cullum V. A., Farmer J. B., Jack D., Levy G. P. Salbutamol: a new, selective beta-adrenoceptive receptor stimulant. Br J Pharmacol. 1969 Jan;35(1):141–151. doi: 10.1111/j.1476-5381.1969.tb07975.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Freedman S., Prowse K. How many blows make an F.E.V.1.0? Lancet. 1966 Sep 17;2(7464):618–619. doi: 10.1016/s0140-6736(66)91928-3. [DOI] [PubMed] [Google Scholar]
- Hartley D., Jack D., Lunts L. H., Ritchie A. C. New class of selective stimulants of beta-adrenergic receptors. Nature. 1968 Aug 24;219(5156):861–862. doi: 10.1038/219861a0. [DOI] [PubMed] [Google Scholar]
- Kennedy M. C., Simpson W. T. Human pharmacological and clinical studies on salbutamol: a specific beta-adrenergic bronchodilator. Br J Dis Chest. 1969 Jul;63(3):165–174. doi: 10.1016/s0007-0971(69)80014-8. [DOI] [PubMed] [Google Scholar]
- Lands A. M., Arnold A., McAuliff J. P., Luduena F. P., Brown T. G., Jr Differentiation of receptor systems activated by sympathomimetic amines. Nature. 1967 May 6;214(5088):597–598. doi: 10.1038/214597a0. [DOI] [PubMed] [Google Scholar]
- Oldham P. D., Hughes D. T. Analysis of the results of bronchodilator trials. Bull Physiopathol Respir (Nancy) 1972 May-Jun;8(3):693–699. [PubMed] [Google Scholar]