Abstract
A 42-year-old haemophiliac who presented with a cholestatic jaundice and repeated gastro-intestinal haemorrhage is described. The bleeding was initially thought to be due to the severity of the haemophilia itself rather than from any local cause and the jaundice thought to be due to a serum hepatitis. The correct diagnosis of ampullary carcinoma was eventually made after numerous barium studies, fibre-optic endoscopy and two laparotomies. A carcinoma was discovered at a second endoscopy some 12 months after initial presentation. Attention is brought to the rare association of ampullary carcinoma and haemophilia, and to the difficulties involved in diagnosis.
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- Biggs R. Jaundice and antibodies directed against factors 8 and 9 in patients treated for haemophilia or Christmas disease in the United Kingdom. Br J Haematol. 1974 Mar;26(3):313–329. doi: 10.1111/j.1365-2141.1974.tb00476.x. [DOI] [PubMed] [Google Scholar]
- Cotton P. B., Rosenberg M. T., Waldram R. P., Axon A. T. Early endoscopy of oesophagus, stomach, and duodenal bulb in patients with haematemesis and melaena. Br Med J. 1973 Jun 2;2(5865):505–509. doi: 10.1136/bmj.2.5865.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Forbes C. D., Barr R. D., Prentice C. R., Douglas A. S. Gastrointestinal bleeding in haemophilia. Q J Med. 1973 Jul;42(167):503–511. [PubMed] [Google Scholar]
- Martel W., Scholtens P. A., Lim L. W. "Tubeless" hypotonic duodenography: technique, value and limitations. Am J Roentgenol Radium Ther Nucl Med. 1969 Sep;107(1):119–130. doi: 10.2214/ajr.107.1.119. [DOI] [PubMed] [Google Scholar]
- Stuart J., Davies S. H., Cumming R. A., Girdwood R. H., Darg A. Haemorrhagic episodes in haemophilia: a 5-year prospective study. Br Med J. 1966 Dec 31;2(5530):1624–1626. doi: 10.1136/bmj.2.5530.1624. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILKINSON J. F., NOUR-ELDIN F., ISRAELS M. C., BARRETT K. E. Haemophilia syndromes. A survey of 267 patients. Lancet. 1961 Oct 28;2(7209):947–950. doi: 10.1016/s0140-6736(61)90791-7. [DOI] [PubMed] [Google Scholar]