Abstract
The effect of dry powder povidone-iodine (Disadine D.P.) on wound healing was assessed experimentally and clinically. It did not interfere with wound healing macroscopically, histologically or mechanically in Wistar rats. One hundred and one patients undergoing 'clean' elective surgery were included in the controlled clinical study and povidone-iodine did not affect wound healing in any way. In the control group 4% of patients developed infection compared with none of those sprayed with povidone-iodine. No adverse reaction to povidone-iodine was seen in either study. This antiseptic offers a safe alternative to antibiotics for use at operation whenever there is risk of wound infection from operative bacterial contamination.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brånemark P. I., Ekholm R. Tissue injury caused by wound disinfectants. J Bone Joint Surg Am. 1967 Jan;49(1):48–62. [PubMed] [Google Scholar]
- Davidson A. I., Smith G., Smylie H. G. A bacteriological study of the immediate environment of a surgical wound. Br J Surg. 1971 May;58(5):326–333. doi: 10.1002/bjs.1800580503. [DOI] [PubMed] [Google Scholar]
- De Haan B. B., Ellis H., Wilks M. The role of infection on wound healing. Surg Gynecol Obstet. 1974 May;138(5):693–700. [PubMed] [Google Scholar]
- Gilmore O. J., Martin T. D. Aetiology and prevention of wound infection in appendicetomy. Br J Surg. 1974 Apr;61(4):281–287. doi: 10.1002/bjs.1800610407. [DOI] [PubMed] [Google Scholar]
- Gilmore O. J., Martin T. D., Fletcher B. N. Prevention of wound infection after appendicectomy. Lancet. 1973 Feb 3;1(7797):220–222. doi: 10.1016/s0140-6736(73)90063-9. [DOI] [PubMed] [Google Scholar]
- Gilmore O. J., Sanderson P. J. Prophylactic interparietal povidone-iodine in abdominal surgery. Br J Surg. 1975 Oct;62(10):792–799. doi: 10.1002/bjs.1800621011. [DOI] [PubMed] [Google Scholar]
- Houang E. T., Gilmore O. J., Reid C., Shaw E. J. Absence of bacterial resistance to povidone iodine. J Clin Pathol. 1976 Aug;29(8):752–755. doi: 10.1136/jcp.29.8.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LJUNGQVIST U. WOUND SEPSIS AFTER CLEAN OPERATIONS. Lancet. 1964 May 16;1(7342):1095–1097. doi: 10.1016/s0140-6736(64)91291-7. [DOI] [PubMed] [Google Scholar]
- PRUDDEN J. F., NISHIHARA G., BAKER L. The acceleration of wound healing with cartilage. I. Surg Gynecol Obstet. 1957 Sep;105(3):283–286. [PubMed] [Google Scholar]
- Pollock A. V., Evans M. Povidone-iodine for the control of surgical wound infection: a controlled clinical trial against topical cephaloridine. Br J Surg. 1975 Apr;62(4):292–294. doi: 10.1002/bjs.1800620410. [DOI] [PubMed] [Google Scholar]