Figure 1.

Sequence comparison between Bok and different Bcl-2 family members. (A) Sequence alignment of Bok with several members of the Bcl-2 family proteins. The ORF for Bok predicts a protein of 213 amino acids in length. Asterisks indicate two potential phosphorylation sites. Shaded residues are identical in at least three of the six Bcl-2 proteins shown. Consensus sequences for these proteins are listed on top of the sequence alignment. The conserved BH domains (1–4) and the C-terminal transmembrane region are indicated. The GenBank accession number for Bok is AF027954. r: rat, m: mouse, h: human. (B) Comparison of BH3 domain sequences in different pro-apoptotic Bcl-2 proteins. (C) Phylogenetic relatedness of different Bcl-2 family members. Full-length polypeptides for all Bcl-2 members except Mcl-1 (amino acids 121–330 only) are used for comparison.