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DNA binding analysis of p53 core domain from DSC. Thermograms were determined in 50 mM Tris, pH 7.2/1 mM DTT of (top trace) double-stranded DNA (dsDNA) oligonucleotide (7 μM) (Tm = 56°C), (middle trace) p53 core domain + dsDNA oligonucleotide equimolar (Tm = 49°C), (bottom trace) p53 core domain (7 μM) (Tm = 42°C) alone. Data are shown without correction for the buffer baseline and are offset for clarity.
