Table 4.

Effect of withdrawal from 14-day chronic nicotine exposure on prepulse inhibition in C57BL/6J and BALB/cByJ mice

Strain	Nicotine Day 1Dose	Day 1	Day 3	Day 5

Prepulse Intensity 74 dB^d
C57BL/6J	0	24.59 ± 7.15	17.33 ± 16.81	36.89 ± 7.14
	10	37.52 ± 6.20	43.04 ± 3.87	39.71 ± 6.27
	20	32.86 ± 4.52	37.02 ± 4.93	34.00 ± 5.04
	30	34.00 ± 6.65	36.85 ± 5.47	26.63 ± 9.07
	40	15.13 ± 6.54	34.82 ± 6.51	37.42 ± 4.44
BALB/cByJ	0	43.10 ± 3.36	43.73 ± 3.29	40.67 ± 7.14
	10	37.33 ± 5.85	47.51 ± 2.91	36.38 ± 4.29
	20	42.13 ± 4.67	41.96 ± 3.78	43.42 ± 4.27
	30	43.37 ± 4.13	45.17 ± 4.35	36.77 ± 5.99
	40	39.56 ± 4.71	41.65 ± 4.99	41.89 ± 6.08
Prepulse Intensity 78 dB
C57BL/6J	0	45.79 ± 5.46	43.69 ± 11.01	57.39 ± 4.92
	10	50.87 ± 5.94	49.23 ± 5.58	51.44 ± 6.69
	20	40.71 ± 4.99	56.16 ± 5.24	52.23 ± 4.26
	30	55.77 ± 3.73	51.73 ± 6.70	47.84 ± 8.15
	40	36.42 ± 5.01	45.93 ± 6.48	47.59 ± 4.47
BALB/cByJ	0	49.99 ± 2.91	48.94 ± 3.69	49.82 ± 3.96
	10	46.08 ± 4.74	51.94 ± 4.49	49.41 ± 4.25
	20	49.14 ± 5.76	48.32 ± 3.71	45.16 ± 3.87
	30	51.71 ± 4.30	48.88 ± 4.58	43.42 ± 7.30
	40	50.65 ± 4.60	43.41 ± 6.03	43.45 ± 5.74
Prepulse Intensity 82 dB^a, ^b, ^c
C57BL/6J	0	52.92 ± 4.98	47.05 ± 10.29	65.60 ± 4.82
	10	59.19 ± 5.10	57.65 ± 4.94	55.24 ± 4.72
	20	53.48 ± 5.17	62.57 ± 4.64	62.00 ± 4.48
	30	57.51 ± 3.43	58.38 ± 5.67	53.24 ± 7.53
	40	39.485.28 ±	49.74 ± 6.79	57.01 ± 4.38
BALB/cByJ	0	57.45 ± 4.22	58.70 ± 3.83	56.98 ± 3.92
	10	52.38 ± 4.26	59.41 ± 2.42	52.93 ± 3.67
	20	55.89 ± 5.02	53.63 ± 3.74	51.01 ± 3.16
	30	64.68 ± 4.08	54.13 ± 3.98	55.34 ± 3.96
	40	58.70 ± 4.41	51.39 ± 2.18	55.38 ± 4.68

Nicotine doses are expressed as mg/kg/day base. Mice were tested on 1, 3, and 5 days of nicotine/saline withdrawal. Data are presented as mean values ± S.E.M.

indicates a significant Strain × Nicotine Dose × Withdrawal Day interaction.

indicates a significant Nicotine Dose × Withdrawal Day interaction.

indicates a significant Strain × Withdrawal Day interaction.

indicates a significant main effect of Strain in a three-way ANOVA (all p < 0.05).