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. 2008 Aug 5;105(32):11388–11393. doi: 10.1073/pnas.0802978105

Fig. 2.

Fig. 2.

The enhancement of the EPSP is mediated by inhibition of EAAT1. (A) Inhibition of EAAT1/2 with TFB-TBOA yielded an enhancement in synaptic responses when added 30 seconds after TBP when compared with responses in the absence of TBOA (open symbols denote experiments with TBOA, filled symbols denote control experiments without TBOA). (B) Selective inhibition of EAAT2 with DHK had little effect on the EPSP. (C) TFB-TBOA enhanced EPSPs when added 5 min after HFS. (D) TFB-TBOA had little effect on EPSCs when added 30 sec after voltage pairing. (E) TFB-TBOA had little effect on EPSPs when added 30 sec after TBP in adult hippocampal neurons. (F) Summary of the effects of TFB-TBOA on synaptic responses under different LTP induction protocols. *, P < 0.05.