Fig. 3.

Accumulation of perisynaptic AMPARs requires postsynaptic exocytosis, PKA signaling, and the C-terminal of GluR1 subunit. (A) TBOA did not enhance EPSPs after TBP in BoTox-loaded neurons (filled) but did in neurons loaded with heat-inactivated BoTox (open). (B) TBOA also had no effect on the EPSP after TBP in neurons loaded with PKI (open), compared with control experiments in the absence of TBOA (filled). (C) Postsynaptic loading of the pep-1 peptide abolished the effect of TBOA (open), compared with control experiments in the absence of TBOA (filled).