Fig. 5.

Persistent actin polymerization is required for the maintenance of perisynaptic AMPARs. (A) latA applied 2 min after TBP did not disrupt the spine expansion that took place immediately after TBP, as shown in sample images (Upper; expanded spines shown with arrows) and population data (Lower). (B) LatA applied 2 min after TBP greatly reduced LTP, even though the spine expansion persisted. (C) TBOA did not enhance synaptic transmission when added at 5 min after TBP (open), compared with control neurons in the absence of TBOA (filled). [Scale bar: 1 μm (A).]