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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Exp Physiol. 2008 May 9;93(7):773–797. doi: 10.1113/expphysiol.2007.041848

Figure 2. Mice deficient in TRPM8 exhibit profoundly diminished responses to cold.

Figure 2

A, the discharge response of cutaneous C fibres to a cold ramp that is seen in wild-type mice (top) mostly disappears in TRPM8-deficient mice (bottom). B, licking and flinching in response to evaporative cooling was measured for 1 min following application of acetone to the hindpaw. The TRPM8-deficient mice displayed significantly decreased behaviour compared with wild-type littermates. C, wild-type and TRPM8-deficient littermates were allowed to choose between adjacent surfaces adjusted to 30°C versus a range of temperatures, as shown. The percentage of time spent at 30°C over a 5 min period is shown. The TRPM8-deficient mice show a clear, but not complete, deficit in their ability to discriminate between cold and warm surfaces. Graphs display means ± s.e.m.; *P < 0.05, **P < 0.01 and ***P < 0.001. Modified with permission from Bautista et al. (2007)