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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Exp Physiol. 2008 May 9;93(7):773–797. doi: 10.1113/expphysiol.2007.041848

Figure 6. Effects of disinhibition and inhibition of rostral raphe pallidus (rRPa) neurons on BAT thermogenesis and body temperature.

Figure 6

A, blockade of GABAA receptors with bicuculline (BIC) in the rRPa dramatically activates BAT sympathetic nerve activity (SNA) and increases BAT temperature, expired CO2, heart rate (HR) and arterial pressure (AP). All of these responses are reversed by nanoinjection of the 5-HT1A agonist, 8-hydroxy-2-(di-N-propylamino)tetralin hydrobromide (8-OH-DPAT), into rRPa. B, the increases in BAT SNA, BAT temperature, expired CO2 and HR produced by a reduction in skin temperature (Tskin) are blocked by inhibition of neural activity in the rRPa with nanoinjection of glycine. B, bottom panel, deposit of fluorescent beads (arrow) indicates the glycine injection site in rRPa. Abbreviations: RMg, raphe magnus; and py, pyramid. Reproduced with permission from Nakamura & Morrison (2007a)). C, falls in body temperature following nanoinjection of muscimol (Musc, arrow) into the rostral ventromedial medulla to inhibit local neurons in awake rats. Asterisk indicates period of significant falls in core temperature. Reproduced with permission from Zaretsky et al. (2003).