Figure 3.

Gross features of newborn mice. (A) Newborn +/+ (left) and −/− (right) mice from the same litter. Note the darkened abdominal region, indicative of a congested liver, and the dome-shaped head, due to hydrocephalus involving the lateral ventricles, in the −/− mouse. The size of the newborn −/− mice varied, and all of them failed to nurse. (B and C) Unopened +/+ (B) and −/− (C) hearts. The −/− heart is more rounded in shape and shows right atrial (RA) dilatation and bulging of the right ventricular outflow tract (∗).