Table 1.

Peak Changes in Physiological Variables in Response to Inhaled l-Methamphetamine, IV phenylephrine and IV l-methamphetamine.

Measure	16 Inhalations	32 Inhalations	64 Inhalations	PE1	PE2	IV l-Meth	Overall P-Value
Systolic Blood Pressure (mmHg)	11.8 (16.2)‡§||**	12.3 (20.5)‡§||**	- 1.2 (16.0)	0.9 (10.1)	1.4 (9.8)	2.9 (9.3)	0.03
Diastolic Blood Pressure (mmHg)	8.7 (8.9)||**	6.6 (9.9)||	9.0 (12.4)||**	1.9 (8.3)	-2 (10.2)	7.4 (12.5)||	0.04
Heart Rate (beats/min)	1.3 (12.3)	4.2 (19.2)	2.3 (14.3)	2.8 (9.7)	-4.2 (7.9)	- 0.33 (8.4)	0.62
Respiratory Rate (breaths/min)	0.17 (4.3)	3 (2.5)*§||**	2.4 (3.5)§||	- 1.9 (4.8)	-1.5 (3.3)	0.42 (4.4)	0.003
Core Temperature (°C)	0.13 (0.8)	- 0.32 (0.9)	0.21 (0.9)	- 0.19(0.6)	0.08 (0.4)	0.09 (0.2)	0.41

Data presented as mean (SD).

PE₁ = phenylephrine dose 1; PE₂ = phenylephrine dose 2; IV l -Meth = IV l-methamphetamine

* = significantly greater than 16 inhalations

† = significantly greater than 32 inhalations

‡ = significantly greater than 64 inhalations

§ = significantly greater than PE₁

|| = significantly greater than PE₂

¶ significantly greater than IV l-methamphetamine

** = significantly greater than baseline