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ER content in the five efficacy groups. Ordinate: ER content (fmol/ml); Abscissa: Sp score (score 1: lowest cell kill of non-resistant cycling cells score 5: highest cell kill). Colours refer to the type of model of the best fit. Blue: Level I (without resistance. Open symbols: resistance undetermined; closed symbols: no resistance); Fuchsia: Level II (with resistance); Green: Level III (without resistance, with biphasic efficacy, Sp calculated on the more effective phase).
