Table 3.
Risk of incident dementia in patients with Diabetus mellitus in longitudinal studies
| Dementia | na | Follow-up (years) | Ageb | Outcomes |
|---|---|---|---|---|
| Any dementia | ||||
| Peila, 2002 | 3508 | 2.9 | 77 | Positive correlation. RR (95% CI) = 1.5 (1.0–2.2) Adjusted RRc (95% CI) = 1.5 (1.0–2.2) |
| Whitmer 2005 | 8845 | 35 | 42 | Positive correlation. RR (95% CI) = 1.5 (1.2–1.8) |
| Schnaider Berri 2004 | 10059 | 35 | 45 | Positive correlation. RR (95% CI) = 2.8 (1.4–5.7) |
| Ott 1999 | 6370 | 2.1 | 69 | Positive correlation. RR (95% CI) = 1.9 (1.3–2.8) |
| Xu 2004 | 1301 | 4.7 | 81 | Positive correlation. RR (95% CI) = 1.5 (1.1–2.1) Adjusted RR (95% CI) = 1.5 (1.0–2.1) |
| Curb 1999 | 3774 | 25 | 53 | Non significant correlation. RR (95% CI) = 1.1 (0.7–1.8) |
| Hassing 2002 | 702 | 6 | 84 | Non significant correlation. Adjusted RR (95% CI) = 1.2 (0.8–1.7) |
| MacKnight 2002 | 9131 | 5 | 74 | Non significant correlation. RR (95% CI) = 1.2 (0.9–1.7) Adjusted RR (95% CI) = 1.3 (0.9–1.8) |
| AD | ||||
| Peila 2002 | 3508 | 2.9 | 77 | Positive correlation. RR (95% CI) = 1.7 (1.0–2.8) |
| Yamada 2003 | 1774 | 30 | 43 | Positive correlation. RR = 4.4 |
| Akomolafe 2006 | 2210 | 12.7 | 70 | Positive correlation. Adjusted RR (95% CI) = 2.98 (1.06–8.9) |
| Ott 1999 | 6370 | 2.1 | 69 | Positive correlation. RR (95% CI) = 1.9 (1.2–3.1) |
| Luchsinger 2001 | 1799 | 4.3 | 76 | Positive correlation. RR (95% CI) = 2.4 (1.8–3.2) Adjusted RR (95% CI) = 2.0 (1.4–2.9) |
| Arvanitakis 2004 | 847 | 5.5 | 75 | Positive correlation. RR (95% CI) = 1.7 (1.1–2.5) |
| Xu 2004 | 1301 | 4.7 | 81 | No significant correlation. RR (95% CI) = 1.3 (0.8–1.9) Adjusted RR (95% CI) = 1.3 (0.9–2.1) |
| Luchsinger 2005 | 1786 | 5.5 | 76 | Positive correlation. RR (95% CI) = 2.4 (1.8–3.2) Adjusted RR (95% CI) = 2.0 (1.4–2.9) |
| Curb 1999 | 3774 | 25 | 53 | Non significant correlation. RR (95% CI) = 1.0 (0.5–2) |
| Hassing 2002 | 702 | 6 | 84 | Non significant correlation. Adjusted RR (95% CI) = 0.8 (0.5–1.5) |
| MacKnight 2002 | 9131 | 5 | 74 | Non significant correlation. RR (95% CI) = 1.2 (0.8–1.8) Adjusted RR (95% CI) = 1.3 (0.8–2.0) |
| VaD | ||||
| Peila 2002 | 3508 | 2.9 | 77 | Positive correlation RR (95% CI) = 2.2 (1.1–4.7) Adjusted RR (95% CI) = 2.3 (1.1–5.0) |
| Yamada 2003 | 1774 | 30 | 43 | Positive correlation. RR = 1.3 (p = 0.06) |
| Ott 1999 | 6370 | 2.1 | 69 | Positive correlation. RR (95% CI) = 2.0 (1.7–5.6) |
| Luchsinger, 2001 | 1799 | 4.3 | 76 | Positive correlation. RR (95% CI) = 4.2 (2.2–8.3) Adjusted RR (95% CI) = 3.4 (1.7–6.9) |
| Hassing 2002 | 702 | 6 | 84 | Positive correlation. Adjusted RR (95% CI) = 2.5 (1.4–4.8) |
| MacKnight, 2002 | 9131 | 5 | 74 | Positive correlation. RR (95% CI) = 2.2 (1.3–3.6) Adjusted RR (95% CI) = 2.0 (1.2–3.6) |
| Xu 2004 | 1301 | 4.7 | 81 | Positive correlation. RR (95% CI) = 2.2 (1.1–5.0) Adjusted RR (95% CI) = 2.6 (1.2–6.1) |
| Curb 1999 | 3774 | 25 | 53 | Non significant correlation. RR (95% CI) = 1.5 (0.8–2.8) |
a
= numbers of subjects at inclusion.
b
at baseline.
c
RR adjusted for vascular risk factors.
Abbreviations: AD, Alzheimer’s disease; RR, relative risk; VaD, vascular dementia.