Table 4.
Association between cholesterol level and dementiain longitudinal studies
| Reference | na (baseline) | Age at baseline (years) | Follow-up (years) | Outcomes |
|---|---|---|---|---|
| Notkola 1998 | 444 | 40–59 | 30 | Positive correlation between TC and AD RR (95% CI = 3.1(1.2–8.5) |
| Kivipelto 2002 | 1449 | 53 | 21 | Positive correlation between TC and AD RR (95% CI) = 2.8 (1.2–6.7) |
| Moroney 1999 | 111 | 75 | 7 | Positive correlation between LDL-C and AD RR (95% CI) = 3.1 (1.5–6.1) |
| Kalmijn 2000 | 8006 | 52.7 | 26 | Non significant correlation between TC and any dementia RR (95% CI) = 1.10 (0.95–1.26) |
| Tan 2003 | 1026 | 76 | 8 | Non significant correlation between TC and AD RR (95% CI) = 0.97 (0.90–1.05) |
| Reitz 2004 | 2820 | 78 | 4.8 | Non significant between LDL-C and AD RR (95% CI) = 0.48 (0.26–0.86) |
| Mielke 2005 | 392 | 70 | 18 | Negative correlation between TC and any dementia RR (95% CI) = 0.31 (0.11–0.85) |
a
n = numbers of subjects at inclusion.
Abbreviations: AD, Alzheimer’s disease; LDL-C, LDL-cholesterol; RR, relative risk; TC, total cholesterol.