Table 3.

Interaction odds ratios between IL2 genotypes and cigarette smoking on cervical and vulvar cancer risk

TagSNP*	Genotype	Cervical cancer cases			Vulvar cancer cases
		Genotype frequency		IOR (95% CI)†	Genotype frequency		IOR (95% CI)
		Smokers	Non-smokers		Smokers	Non-smokers
rs2069762	TT	0.54	0.51	1.00	0.42	0.56	1.00
	TG	0.37	0.42	0.85 (0.55–1.32)	0.50	0.38	1.69 (1.15–2.47)
	GG	0.09	0.07	1.29 (0.60–2.80)	0.08	0.06	1.59 (0.76–3.32)
	TG or GG vs. TT‡			0.91 (0.60–1.38)			1.67 (1.16–2.41)
	GG vs. TT or TG§			1.39 (0.66–2.93)			1.24 (0.61–2.54)
rs2069763	GG	0.44	0.42	1.00	0.44	0.43	1.00
	GT	0.39	0.48	0.79 (0.50–1.25)	0.48	0.49	0.98 (0.67–1.44)
	TT	0.17	0.10	1.66 (0.86–3.22)	0.08	0.08	0.98 (0.48–1.97)
	GT or TT vs. GG‡			0.94 (0.61–1.43)			0.98 (0.68–1.42)
	TT vs. GG or GT§			1.87 (1.00–3.48)			0.99 (0.50–1.94)
rs2069777	CC	0.86	0.85	1.00	0.86	0.80	1.00
	CT	0.14	0.15	0.96 (0.53–1.74)	0.14	0.19	0.65 (0.39–1.06)
	TT			–	0.01	0.01	0.72 (0.04–11.6)
	CT or TT vs. CC‡			–			0.65 (0.40–1.06)
	TT vs. CC or CT§			–			0.77 (0.05–12.40)
rs2069778	CC	0.74	0.68	1.00	0.66	0.69	1.00
	CT	0.22	0.28	0.70 (0.43–1.16)	0.31	0.29	1.17 (0.78–1.75)
	TT	0.04	0.04	1.15 (0.40–3.33)	0.03	0.02	1.42 (0.41–4.95)
	CT or TT vs. CC‡			0.75 (0.47–1.20)			1.18 (0.80–1.80)
	TT vs. CC or CT§			1.26 (0.44–3.62)			1.35 (0.39–4.69)

^*rs number refers to the National Center for Bioinformatics (NCBI) dbSNP build 127 reference sequence number.

^†IOR, interaction odds ratio; CI, confidence interval.

^‡Dominant genetic model.

^§Recessive genetic model.