Table 5.
Interaction odds ratios between IL2 diplotypes and cigarette smoking on cervical and vulvar cancer risk
| Diplotype* | Cervical cancer cases | Vulvar cancer cases | ||||
|---|---|---|---|---|---|---|
| Diplotype frequency | IOR (95% CI)† | Diplotype frequency | IOR (95% CI) | |||
| Smokers | Non-smokers | Smokers | Non-smokers | |||
| TTCC / GGCC | 0.18 | 0.22 | 1.00 | 0.25 | 0.20 | 1.00 |
| TTCC / TTCC | 0.17 | 0.10 | 2.08 (1.01–4.30) | 0.08 | 0.08 | 0.85 (0.41–1.78) |
| TTCC / TGCT | 0.08 | 0.12 | 0.83 (0.37–1.87) | 0.11 | 0.11 | 0.82 (0.43–1.56) |
| TTCC / TGCC | 0.11 | 0.08 | 1.69 (0.76–3.79) | 0.07 | 0.08 | 0.74 (0.36–1.51) |
| TGCT / GGCC | 0.08 | 0.09 | 1.09 (0.47–2.53) | 0.13 | 0.05 | 2.09 (0.98–4.46) |
| GGCC / GGCC | 0.09 | 0.07 | 1.68 (0.72–3.95) | 0.07 | 0.06 | 0.97 (0.44–2.13) |
| TGCC / GGCC | 0.05 | 0.06 | 1.05 (0.41–2.72) | 0.05 | 0.08 | 0.55 (0.26–1.17) |
| TTCC / TGTC | 0.03 | 0.05 | 0.72 (0.22–2.34) | 0.04 | 0.09 | 0.37 (0.16–0.85) |
| TGTC / GGCC | 0.06 | 0.04 | 1.70 (0.63–4.58) | 0.05 | 0.03 | 1.25 (0.47–3.33) |
| TGCT / TGCC | 0.03 | 0.06 | 0.65 (0.20–2.08) | 0.03 | 0.08 | 0.37 (0.15–0.87) |
| TGCT / TGCT | 0.04 | 0.03 | 1.66 (0.54–5.11) | 0.02 | 0.02 | 0.95 (0.26–3.47) |
| TGCT / TGTC | 0.03 | 0.02 | 2.28 (0.55–9.37) | 0.03 | 0.04 | 0.53 (0.19–1.45) |
| TGCC / TGCC | 0.02 | 0.02 | 1.65 (0.38–7.19) | 0.02 | 0.02 | 0.72 (0.20–2.55) |
| TGCC / TGTC | 0.02 | 0.04 | 0.77 (0.20–3.04) | 0.01 | 0.03 | 0.35 (0.10–1.22) |
*
The two haplotypes carried on each chromosome are separated by the “/”. Alleles in each haplotype are listed from 5′ to 3′ (rs2069762, rs2069763, rs2069777, and rs2069778). Variant alleles are underlined.
†
IOR, interaction odds ratio; CI, confidence interval.