Table 3.
Characteristics of surviving patients
pt # | age | sex | diagnosis | year of initial dx | year of recurrence | primary site | metastasis or recurrence at enrollment | Cytoreductive therapy | status post frontline chemotherapy | IL-2 | T cells (×106)/kg | completed Rx | immune response | OS (years) | Follow Up |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
New Dx with metastasis | |||||||||||||||
3 | 16 | M | AR | 1998 | NA | Bladder | bladder, lymph nodes, bone marrow | chemo, SCT, XRT | CR | mod | 124.4 | y | + | 9.2 | NED* |
13 | 33 | M | ESFT | 2000 | NA | L femur | L femur with pulmonary mets | chemo, XRT | CR | low | 207.2 | y | − | 7.2 | NED* |
29 | 11 | F | ESFT | 2002 | NA | R fibula | R fibula & pulmonary | chemo, XRT | CR | none | 99.6 | y | − | 5.3 | NED* |
Recurrence (>1yr after frontline therapy) | |||||||||||||||
22 | 18 | F | AR | 1998 | 2000 | R neck/sinus | breast | chemo, SX | CR | low | 153.3 | y | − | 7.3 | NED* |
6 | 39 | M | ESFT | 1983 | 1998 | 10th L rib | R diaphragm | chemo, SX | PR | mod | 108.9 | y | + | 9.7 | recurred; currently NED × one year |
10 | 3 | F | AR | 1995 | 1998 | R orbit | R pre-auricular LN | SX, chemo, SCT | PD | mod | 249.6 | n | + | 9.4 | disease progression during immunotherapy, currently NED for > 5 years |
11 | 28 | M | ESFT | 1980 | 1998 | L tibia | pulmonary mets | chemo | CR | mod | 74.0 | y | + | 9.4 | recurred; currently NED for > 3 years |
5 | 16 | F | ESFT | 1995 | 1998 | R thigh | kidney | chemo | CR | mod | 203.0 | y | + | 9.1 | NED* |
16 | 21 | M | ESFT | 1991 | 2001 | Neck | neck | chemo | CR | low | 141.7 | y | − | 6.6 | NED* |
20 | 6 | F | AR | 1997 | 2000 | L ankle | s/p resection of local recurrence | chemo | CR | low | 244.5 | y | − | 7.8 | NED* |
27 | 26 | F | ESFT | 1994 | 2002 | R arm | R clavicle/L pleural mass with rib/pulmonary | XRT, chemo | PR | none | 197.2 | y | − | 5.1 | recurred; currently NED for > 3 years |
Abbreviation: dx, diagnosis; NA, not applicable; LN, lymph node; SX, surgery; SCT, stem cell transplant; XRT, radiation treatment; CR, complete response; PR, partial response; PD, progression of disease; IL-2, interleukin 2; mod, moderate; OS, overall survival; AWD, alive with disease; NED, no evidence of disease.
NED since initiating immunotherapy