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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Bioconjug Chem. 2008 Jun 20;19(7):1439–1447. doi: 10.1021/bc800050x

Table 2.

Biodistribution of ligands radiolabeled with 177Lu in Non-Tumor Bearing Athymic Mice.

Ligand Tissue Timpoints (hr)
0.50 1.00 4.00 8.00 24.00
C-NE3TA Blood 0.93 ± 0.30 0.31 ± 0.04 0.12 ± 0.02 0.06 ± 0.01 0.01 ± 0.00
Liver 0.82 ± 0.27 0.69 ± 0.20 0.50 ± 0.02 0.36 ± 0.05 0.31 ± 0.04
Spleen 0.33 ± 0.08 0.28 ± 0.20 0.19 ± 0.07 0.13 ± 0.02 0.12 ± 0.05
Kidney 2.78 ± 0.99 1.57 ± 0.52 1.34 ± 0.09 1.16 ± 0.19 0.84 ± 0.08
Lung 0.87 ± 0.22 0.42 ± 0.16 0.17 ± 0.03 0.15 ± 0.03 0.07 ± 0.03
Heart 0.37 ± 0.08 0.19 ± 0.09 0.08 ± 0.02 0.10 ± 0.11 0.02 ± 0.01
Femur 1.06 ± 1.35 0.39 ± 0.13 0.36 ± 0.11 0.28 ± 0.15 0.38 ± 0.10
C-NETA* Blood 0.91 ± 0.41 0.34 ± 0.55 0.03 ± 0.00 0.01 ± 0.00 0.00 ± 0.00
Liver 0.56 ± 0.21 0.25 ± 0.034 0.16 ± 0.04 0.13 ± 0.03 0.08 ± 0.01
Spleen 0.54 ± 0.38 0.15 ± 0.11 0.07 ± 0.01 0.07 ± 0.03 0.05 ± 0.03
Kidney 2.98 ± 1.24 1.19 ± 0.47 1.07 ± 0.20 0.87 ± 0.24 0.59 ± 0.12
Lung 0.88 ± 0.41 0.26 ± 0.08 0.10 ± 0.06 0.04 ± 0.01 0.03 ± 0.01
Heart 0.43 ± 0.16 0.11 ± 0.04 0.04 ± 0.01 0.03 ± 0.01 0.02 ± 0.01
Femur 0.66 ± 0.13 0.53 ± 0.24 0.19 ± 0.05 0.17 ± 0.01 0.19 ± 0.08

Values are the percent injected dose per gram(% ID/g) ± standard deviation

*

The data were cited for comparison (26).