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Mouse SUR1 and mouse Kir6.2 coexpressed in Xenopus oocytes generate KATP channels. (A) Macroscopic currents from a representative inside-out patch in symmetrical 150 mM KCl at −80 mV. ATP at the indicated concentrations was superfused onto the cytoplasmic face of the patch. (B) Hill fit to data from eight oocytes. (C) Single channel currents at voltages from −120 to 60 mV in symmetrical 150 mM KCl and no ATP. (D) Linear fit to single-channel current amplitude as a function of voltage.
