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. 1998 Nov 10;95(23):13953–13958. doi: 10.1073/pnas.95.23.13953

Figure 4.

Figure 4

Kir6.2∷T171A and Kir6.2∷I182Q have low ATP sensitivity. (A) Representative single-channel currents at −80 mV from channels formed by coexpression of Kir6.2∷T171A and SUR1. The mutant channels exhibit moderate decrease in ATP sensitivity, exemplified by lowered but still substantial activity in the presence of 1,000 μM ATP. (B) Single channel currents at −80 mV from channels formed by Kir6.2∷I182Q and SUR1. The decrease in channel activity in response to low [ATP] is typical for this mutant. These channels are not detectably inhibited by ATP and appear to run down rapidly when [ATP] is below 10 μM.