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. 1998 Nov 10;95(23):13953–13958. doi: 10.1073/pnas.95.23.13953

Figure 5.

Figure 5

Long-lived closed times of truncated Kir6.2ΔC26 largely fit into a single kinetic component and increase with [ATP]. (A) Truncated channel in the absence of SUR1. Top two traces in the absence of added ATP. Notice the very short bursts of openings and frequent long-lived closed times even in the absence of ATP. Bottom two traces at the [ATP] indicated. (B) Wild-type KATP channels. Notice the long bursts of openings and relatively rare long-lived closed times. (C) Open-time histograms of the truncated Kir6.2ΔC26 channel in the absence of SUR1 at the indicated [ATP], representative of four similar experiments. (D) Closed time histograms of the truncated Kir6.2ΔC26 channel in the absence of SUR1 at the indicated [ATP], representative of four similar experiments. The event duration histogram construction and fitting (12) results in a function of peaked exponential terms. The time constant of each term is specified by the x coordinate of the peak, indicated in the histograms by an open box. All currents were recorded at −80 mV.