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. 1997 Nov 11;94(23):12437–12441. doi: 10.1073/pnas.94.23.12437

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Copyright © 1997, The National Academy of Sciences of the USA

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Effect of 25-hydroxycholesterol is probably mediated by OSBP. (A) Effects of various oxysterols on the secretion of α-tocopherol from McA-TTP21 cells. McA-TTP21 cells were incubated in the presence of 25-hydroxycholesterol (2.5 μg/ml, lane 1), 20-hydroxycholesterol (lane 2), or 7-ketocholesterol (lane 3). After a 24-h incubation, the radioactivities of the cell and medium fractions were measured. The results are expressed relative to values for cells incubated without additives. Each point represents the mean ± SE of triplicate determinations. (B) 25-Hydroxycholesterol-mediated suppression of the secretion of α-tocopherol from McA-TTP21 cells in the presence of BFA. McA-TTP21 cells were incubated in the presence of 25-hydroxycholesterol (2.5 μg/ml) with various concentrations of BFA. After a 24-h incubation, the radioactivities of the cell and medium fractions were measured. The results are expressed relative to values for cells incubated without additives. Each point represents the mean ± SE of triplicate determinations.