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A two-allele selection model to describe the segregation observed in families for HLA-A and HLA-B
| Parents
|
Progeny | |||
|---|---|---|---|---|
| Female × Male | Frequency | A1A1 | A1A2 | A2A2 |
| A1A1 × A1A1 | P112 | 1 | — | — |
| A1A1 × A1A2 | P11P12 | 1 | 1 | — |
| A1A1 × A2A2 | P11P22 | — | 1 | — |
| A1A2 × A1A1 | P11P12 | 1 − s | 1 | — |
| A1A2 × A1A2 | P122 | 1 − s | 1 | 1 − s |
| A1A2 × A2A2 | P12P22 | — | 1 | 1 − s |
| A2A2 × A1A1 | P11P22 | — | 1 | — |
| A2A2 × A1A2 | P12P22 | — | 1 | 1 |
| A2A2 × A2A2 | P222 | — | — | 1 |
| p1(p1 − ½ sP12) | 2p1p2 | p2(p2 − ½ sP12) | ||
| 1 − ½ sP12 | 1 − ½ sP12 | 1 − ½ sP12 | ||
