Table 4.

GSRS and GIQLI scores by physician's rating of clinical disease severity at baseline

	Groups by rating of clinical severity				Kruskall-Wallis Test of overall differences
Patient reported outcome instrument and domain	None (n = 20) mean (SD)	Mild (n = 6) mean (SD)	Moderate (n = 32) mean (SD)	Severe (n = 4) mean (SD)	Chi-Square	p-value	Wilcoxon rank-sum tests (pairwise comparisons with p < 0.001)
GSRS Abdominal Pain	1.33 (0.42)	2.61 (0.93)	3.29 (1.23)	3.83 (1.69)	33.75	<0.001	b
GSRS Reflux Syndrome	1.10 (0.26)	2.42 (1.32)	3.09 (1.46)	4.00 (2.12)	29.25	<0.001	b, c
GSRS Diarrhea	1.12 (0.20)	3.61 (1.69)	3.57 (1.56)	2.67 (1.70)	37.21	<0.001	a, b
GSRS Indigestion Syndrome	1.29 (0.33)	3.29 (1.81)	3.76 (1.43)	4.81 (1.68)	38.29	<0.001	a, b
GSRS Constipation	1.20 (0.38)	1.94 (0.65)	2.55 (1.26)	3.42 (2.23)	27.03	<0.001	b
GIQLI Total Score	126.00 (10.97)	95.83 (23.22)	87.02 (22.08)	65.00 (37.37)	33.25	<0.001	b
GIQLI Symptoms	3.64 (0.30)	2.65 (0.68)	2.49 (0.57)	1.87 (0.82)	35.31	<0.001	b
GIQLI Emotion	3.24 (0.64)	2.87 (0.70)	2.47 (0.74)	1.60 (0.86)	16.33	<0.001
GIQLI Physical Function	3.21 (0.61)	2.14 (0.89)	1.92 (0.91)	1.61 (1.62)	22.00	<0.001	b
GIQLI Social Function	3.55 (0.60)	3.04 (0.70)	2.74 (0.96)	2.19 (1.60)	10.22	0.017
GIQLI Medical Treatment	3.95 (0.22)	4.00 (0.00)	2.94 (1.11)	1.50 (1.91)	21.25	<0.001	b, c

Comparisons not significant unless noted.

a = none vs. mild; b = none vs. moderate; c = none vs. severe;

d = mild vs. moderate; e = mild vs. severe; f = moderate vs. severe.