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. Author manuscript; available in PMC: 2008 Aug 7.
Published in final edited form as: Development. 2005 Mar 16;132(8):1819–1830. doi: 10.1242/dev.01724

Figure 7. TNotch can suppress Wingless signalling induced by the loss of function of GSK3ß/Shaggy.

Figure 7

Wing pouch regions of third intar larval discs with clones of cells mutant for sgg marked by the absence of GFP (green) in a wild type background or in which TNotch is expressed in the clones. Anterior is to the left and posterior to the right. (A-D) Detail of a third larval instar wing disc harbouring clones of cells mutant for shaggy. (A, B) Loss of sgg function (black in A and C) leads to ectopic expression of the high threshold target of Wingless signalling Senseless (blue in B) and ectopic elevation of Armadillo (red in D). (E-H) Clones of cells lacking sgg which also express TNotch. TNotch reduces the ectopic expression of Senseless (F) and the elevation of Armadillo (H). The effects on senseless is fully penetrant but that on Armadillo can be variable (A. Martinez Arias unpublished).