Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Aug 11;182(3):587–601. doi: 10.1083/jcb.200709177

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 Noda et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 10. — Model of the mechanism initiating AQP2 trafficking. Under basal conditions, AQP2 binds to G-actin (A). Vasopressin-triggered cAMP signaling induces PKA phosphorylation of AQP2. AQP2 phosphorylation dissociates G-actin from AQP2 (B) and promotes AQP2 association with TM5b (C). Sequestering of TM5b from F-actin by phosphorylated AQP2 induces destabilization of the F-actin network in the vicinity of AQP2, allowing efficient transport of AQP2 toward the apical membrane.