Table 1.
Demographics, Growth, Menarche and Iron Assessment Variables by Subject Diagnosis
| Variable | THAL (n=152) | Tx-SCD (n=203) | NonTx-SCD (n=65) | p-value (Thal vs. Tx- SCD) | p-value (TxSCD vs. NonTx- SCD) | |
|---|---|---|---|---|---|---|
| Age, years | Mean (SD) | 25.5 (8.1) | 24.7 (13.2) | 25.1 (11.4) | NS | NS |
| Subjects, > 18 yrs | N (%) | 118 (77.6) | 101 (49.8) | 41 (63.1) | <0.001 | NS |
| Male | N (%) | 80 (52.6) | 88 (43.4) | 33 (50.7) | NS | NS |
| Weight Z-score | Mean (SD) | −1.1 (1.4) | −0.3 (1.3) | −0.4 (1.2) | <0.001 | NS |
| Height Z-score | Mean (SD) | −1.6 (1.2) | −0.6 (1.3) | −0.1 (1.1) | <0.001 | 0.04 |
| Age at Menarche, y c | Mean (SD) | 14.3 (2.3) | 13.9 (2.2) | 14.9 (1.9) | NS | 0.05 |
| Serum Ferritin, ng/mL d | Mean (SD) | 3605 (2322) | 4338 (3013) | 108 (83) | <0.001 | <0.001 |
| Transfusion Duration, y | Mean (SD) | 21.3 (8.8) | 9.8 (7.2) | <0.001 | -- | |
| Range | (0.6–42.5) | (0.3–40.2) | --- | |||
| Any Endocrinopathy e | % | 85 (55.9) | 26 (12.8) | 5 (7.7) | <0.001 | NS |
a
For continuous variables, p-value for the difference between two groups is based on Student’s t-test. For categorical variables, p-value for the difference between groups is based on Pearson’s chi-square test.
b
BMI= Body Mass Index, kg/m2
c
Age at onset of menarche from only those females who successfully achieved menarche by the time of the baseline evaluation
d
Serum ferritin, is the average of 2 to 3 values analyzed within the previous 12 months. Mean values are provided in the table. Due to the skewness of these data, log transformed values were used in all analyses
e
Any endocrinopathy included evidence of diabetes, growth failure, hypogonadism or hypothyroidism.