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. 2008 Aug 13;3(8):e2923. doi: 10.1371/journal.pone.0002923

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Wan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Two ferrets were inoculated i.n. with 10⁶ TCID₅₀ for each virus: mWF10, RGWF10 or 2WF10:6M98. At day 4 p.i, ferrets were euthanized and the tracheas and lungs were harvested for histological analysis. (A) Histopathological findings in the respiratory tract. Upper panel, tracheas: note the margination of neutrophils (▾) and mononuclear cells (↑) in a small vein in the 2WF10:6M98-infected trachea. Lower panel, lungs: note the severe inflammatory infiltration in the 2WF10:6M98-infected lung. (B) Tissue tropism in organs collected from ferrets inoculated with mWF10, RGWF10, or 2WF10:6M98 virus. OB, olfactory bulb. NT, nasal turbinate.