Table 1.
Cardiomyocyte mechanics
Significance | Wild Type | Homozygote Mutant | |
---|---|---|---|
Myocyte length* (µm) | 64 ± 2 | 106 ± 3 | P< 0.001 |
Myocyte width* (µm) | 28 ± 2 | 67 ± 4 | P<0.001 |
Slack sarcomere length (µm) | 1.88 ± 0.04 | 2.02 ± 0.04 | P<0.01 |
Mean failure sarcomere length (µm) | 2.48 ± 0.05 | No failure to SL > 4.0 µm | |
Mean percent stretch at failure | 32 ± 2 | No failure at 100% stretch | |
Mean failure force (N/m2) | 2.66 ± 0.32 | >5.18 ± 0.74 (last recorded force) |
Myocyte length and width measurements were obtained from images of bulk digests.