Table 2.

Therapeutic effect of immune serum against OspC 60 days after infection of C.B.-17 SCID mice with 10³ B. burgdorferi ZS7

Anti-OspC serum, μg/mouse	Intervals of serum transfer, days p.i.	Mouse	Clinical arthritis (days p.i.)						Ear culture of spirochetes
			10	19	60	70	80	100	1st (d38)	2nd (d80)
0.3	10, 14, 19, 22	1	−/−	+/++	++/++	++/++	++/++	n.d.	n.d.	+
		2	−/−	++/++	++/++	++/++	++/++	n.d.	n.d.	+
		3	−/−	++/++	++/++	++/++	++/++	n.d.	n.d.	+
10	60, 63, 66, 70	1	−/−	+/+	++/++	±/+	−/±	−/±	+	−
		2	−/−	++/+	++/++	±/±	−/−	*	+	−
		3	(±)/−	++/++	++/++	+/++	−/(±)	−/(±)	+	−

The same protocol for infection of mice and the same scoring system for clinical arthritis as described in Table 1 was used. n.d., not determined. 

^*The mouse was sacrificed for histopathological examination.