Table 3.

Frequency of side effects (400 mg/day dose)

Symptom	Any grade %	Grade 3 or 4 %
Anemia	89	7
Oedema	71	2
Fatigue	68	6
Pleuritic pain	51	4
Nausea	49	3
Diarrhoea	48	2
Leucopenia	43	3
Granulocytopenia	41	7
Rash	27	2
Vomiting	26	3
Anorexia	26	2
Myalgia	24	0
Pruritus	16	1
Constipation	16	1

Derived from Verweij et al 2004.