Table 1.

Summary of open-label trials assessing effects of PPI therapy on symptoms of LPR

Study	No of patients	Inclusion criteria	Medication	Duration of treatment (wk)	Outcome measure
Kamel (1994)	16	Persisting LPR symptoms and signs despite prior H2RA treatment	Omeprazole 40 mg od, increased to 40 mg bid in 6 pt.s with ongoing symptoms	6–24	Unspecified change from baseline in mean composite symptom score
Hanson (1995)	41	LPR symptoms and signs unresponsive to nocturnal anti-reflux precautions	Omeprazole 40 mg od	4	Resolution of symptoms
Jaspersen (1996)	21	LPR symptoms and signs and oesophagitis at upper GI endoscopy	Omeprazole 40 mg od	4	Resolution of symptoms
Shaw (1997)	96	LPR symptoms	Omeprazole 20 mg od	12	Unspecified improvement in symptoms
Wo (1997)	21	LPR symptoms and signs	Omeprazole 40 mg od	8	Resolution of symptoms or patient reported satisfactory effect of treatment
Habermann (1999)	29	Voice disorders and symptoms of LPR	Pantoprazole 40 mg od	6	Unspecified change from baseline in mean composite symptom score
Delgaudio (2003)	30	LPR symptoms	Esomeprazole 40 mg od	8	Reduction of at least 50% in symptom score and remaining symptoms no morte than mild in severity
Park (2005)	85	LPR symptoms and signs	Lansoprazole 30 mg bid (n = 30), omprazole 20 mg bid (n = 30), esomprazole 40 mg od (n = 25)	16	Reduction of at least 50% in primary symptom score

Abbreviations: LPR, laryngopharyngeal reflux; PPI, proton pump inhibitor.