Table 2.

Summary of randomized, double-blind, placebo controlled trials of PPI in LPR

Study	No of patients	Inclusion criteria	Important exclusion criteria	Medication	Duration of treatment (wk)	Outcome measure for symptoms	Significant difference between PPI and placebo
Havas (1999)	15	Symptoms and laryngoscopic signs of LPR	Pre-existing anti-secretory medication, severe oesophagitis at endoscopy	Lansoprazole 30 mg bd	12	Significant reduction in mean composite symptom score	No
Noordzij (2001)	30	Symptoms of LPR for min 3 months and abnormal result of hypopharyngeal pH monitoring	Infection, cancer, allergies	Omeprazole 40 mg bd	8	Significant reduction in mean composite symptom score	No
El-Serag (2001)	22	Symptoms for ≥3 wks and laryngoscopic signs of LPR	Infection, cancer, allergies	Lansoprazole 30 mg bd	12	Complete symptom resolution	Yes?
Eherer (2003)	21	Hoarseness for ≥8 wks and laryngoscopic signs of LPR	Smokers	Pantoprazole 40 mg bd	12	Significant reduction in mean composite symptom score	No
Steward (2004)	42	Symptoms for ≥4 wks and laryngoscopic signs of LPR	Current or recent (within 1 mth) use of H2RA or PPI	Rabeprazole 20 mg bd	8	Significant improvement in mean composite symptom score	No
Wo (2006)	39	Symptoms and laryngoscopic signs of LPR. Abnormal triple- sensor pH monitoring	Previous treatment of GERD	Pantoprazole 20 mg od	12	Patient reported global adequate relief of symptoms	No
Vaezi (2006)	146	Laryngeal symptoms for ≥12 wks and laryngoscopic signs of LPR	Moderate to severe heartburn in 3 weeks prior to enrollment	Esomeprazole 40 mg bd	16	Resolution of most bothersome symptom	No

Abbreviations: GERD, gastro-oesophageal reflux disease; LPR, laryngopharyngeal reflux; PPI, proton pump inhibitor.