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. 2008 Jul 17;3:29. doi: 10.1186/1749-799X-3-29

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Copyright © 2008 Wu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A). The 3D collagen network (33 μm × 33 um ×) of the cartilage with a matte surface (ICRS Grade 1–2 in Fig 5(C)) obtained from human femoral heads is disrupted and compromised of the collagen fibres aligning predominantly in a direction spatially perpendicular to the AC surface. (A1). The 3D collagen network (33 μm × 33 um) of fibrillated cartilage (ICRS grade 3 in Fig 5(C1)) has an abnormal microstructure and collagen orientation. Images (B)-(B1) are the corresponding MBIs of images (A) and (A1), which are analogous to en face 2D images. Images (C)-(C1) are the corresponding histological images used for ICRS grading.