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. 2008 Jun 24;5(6):e137. doi: 10.1371/journal.pmed.0050137

Figure 7. Pharmacological Studies of A2BAR Signaling during Renal Ischemia and Preconditioning.

Figure 7

A2BAR antagonist (PSB1115): Age-, weight-, and gender-matched C57BL/6J underwent right nephrectomy. Prior to the surgery, immediately before ischemia, 5 min or 2 h after ischemia, they received the selective A2BAR antagonist PSB1115 (5 mg/kg, intravenous) or treatment with a vehicle control. They were exposed to 45 min of left renal artery ischemia with or without prior in situ IP (consisting of four cycles of 4 min ischemia followed by 4 min of reperfusion). (A) Plasma creatinine and (B) GFR as assessed by inulin clearance were obtained after 24 h of reperfusion.

Statistics: One-way ANOVA with Tukey's post-hoc test was performed (*, p < 0.001 versus the respective group without IP; **, p < 0.001 versus WT mice with IP and with PSB115 treatment). The F-test results are (A) F (9,54) = 42.20, p < 0.001; (B) F (9,55) = 51.67, p < 0.001.