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. 2008 Jun 24;5(6):e137. doi: 10.1371/journal.pmed.0050137

Figure 11. Renal Ischemia and Preconditioning in A2A/A2B AR Bone Marrow Chimeric Mice.

Figure 11

A2BAR+/+ (A2BWT) or A2BAR−/− (A2BKO) mice underwent lethal radiation followed by bone marrow transplantation with marrow derived from A2AAR+/+ (A2AWT) or A2AAR−/− (A2AKO) mice. Experiments were performed 8 wk following transplantation. Mice underwent right nephrectomy and underwent 45 min of left renal artery ischemia with or without prior IP (consisting of four cycles of 4 min ischemia followed by 4 min reperfusion). Following 24 h of reperfusion time, (A) plasma creatinine and (B) GFRs were measured.

Statistics: One-way ANOVA with Tukey's post-hoc test was performed (**, p < 0.001 versus the respective group with IP; *, p < 0.001 versus A2AWT→A2BKO). The F-test results are (A) F (7,40) = 32.45, p < 0.001; (B) F (7,40) = 29.67, p < 0.001.