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Daily change in mean morning peak expiratory flow (PEF) achieved with once-daily budesonide/formoterol (160/4.5 μg; two inhalations), twice-daily budesonide/formoterol (160/4.5 μg; one inhalation), or once-daily budesonide (400 μg). Reproduced with permission from Buhl R, Creemers JP, Vondra V, et al. 2003. Once-daily budesonide/formoterol in a single inhaler in adults with moderate persistent asthma. Respir Med, 97:323–30. Copyright © 2003 Elsevier Ltd.
