Table 1.

Dosage and scheduling of bisphosphonates used for treatment of bony metastasis from breast cancer

Bisphosphonate	Standard dosage (mg)	Route of administration	Duration of infusion	Frequency of administration
Clodronate	1600–3200	oral	NA	twice daily
Ibandronate	50	oral	NA	daily
Ibandronate	6	intravenous	1–2 hours	every 3–4 weeks
Pamidronate	90	intravenous	2 hours	every 3–4 weeks
Zoledronic acid	4	intravenous	15 minutes	every 3–4 weeks