Hemoglobin response rates were signifi cantly higher in the group with additional IV iron during ESA treatment, 93% vs 53%, and the response (Hb increase >2 g/dl)was twice as quick in this group. Copyright © 2007. Reproduced from Hedenus M, Birgegård G, Näsman P, et al 2007. Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study. Leukemia, 21:627–32.