EFFECT OF NALTREXONE AND ONDANSETRON ON ALCOHOL CUE-INDUCED ACTIVATION OF THE VENTRAL STRIATUM IN ALCOHOL-DEPENDENT PEOPLE

Alcohol-Beverage Comparison
Group	Side	X	Y	Z	t score	Regions
Naltrexone	L	−8	43	53	4.44	superior medial frontal
	R	3	−92	16	5.27	cuneus
	R	4	−95	12	7.83	calcarine
Ondansetron	R	29	−88	24	4.29	occipital
	R	8	−68	3	4.07	lingual
Nal + Ond	R	5	62	31	6.05	superior medial frontal
	L	−1	26	31	4.37	ant-cingular
	L	−45	−77	24	5.08	middle occipital
	R	34	−81	27	4.22	middle occipital
	R	4	−91	21	4.51	cuneus
	L	−1	−61	17	8.01	calcarine
	L	−39	27	−14	6.54	inferior orbital frontal
	R	3	−79	−16	4.43	cerebelum
Placebo	L	−18	41	40	5.49	superior frontal
	L	−2	−37	35	4.56	mid-cingulate
	R	1	90	20	5.29	cuneus
	L	−3	−57	16	4.93	calcarine
	R	5	63	18	5.53	superior medial frontal
	R	17	−18	1	4.13	thalamus
	R	1	59	−3	4.03	med-frontal
	R	8	7	−8	5.01	ventral striatum
	L	−21	−23	−14	4.25	parahippocampus
	R	14	69	−15	4.93	cerebelum
	R	29	−42	−18	4.77	fusiform
Social Drinking	L	−7	−99	9	3.99	calcarine

Alcohol-Visual Control Comparison
Naltrexone	L	−9	63	30	4.26	superior medial frontal
	R	4	−94	7	4.96	calcarine
	L	−24	−93	−15	7.52	lingual
	R	25	−78	−18	5.85	cerebelum
Ondansetron	L	−13	39	51	4.87	superior frontal
	L	−25	−76	43	4.23	occipital
	R	1	3	35	4.17	anti-cingular
	L	−7	60	32	4.15	superior medial frontal
	R	32	−90	20	5.52	occipital
	L	−1	−69	12	6.44	calcarine
	R	23	−25	−11	4.91	hippocampus
	L	−23	−32	−12	4.87	parahippocampus
Nal + Ond	L	−10	50	46	4.64	superior medial frontal
	R	17	48	45	4.39	superior frontal
	R	11	−94	20	4.72	occipital
	R	2	−91	7	6.42	calcarine
	L	−23	−28	−10	4.51	hippocampus
Placebo	L	−2	36	51	5.51	superior medial frontal
	L	−20	−81	45	4.76	cuneus
	L	−17	47	38	4.67	superior frontal
	R	1	−91	17	4.94	cuneus
	L	−8	53	9	4.31	anti-cingular
	L	−15	4	3	5.07	pallidum
	R	1	−82	−2	7.65	calcarine
	R	9	6	−8	4.78	ventral striatum
	L	−26	−29	−12	4.49	parahippocampus
	R	25	−30	−14	4.67	parahippocampus
	L	−35	30	−18	4.85	inferior orbital frontal
	R	39	−69	−22	5.25	cerebelum
	L	−31	−49	−22	5.46	cerebelum
Social Drinking	L	−19	−100	−10	4.16	lingual

Beverage-Visual Control Comparison
Naltrexone	No activation
Ondansetron	R	17	−18	70	5.65	precentral gyrus
Nal + Ond	R	28	−96	−4	4.56	occipital
	L	−15	−101	−8	5.83	lingual
Placebo	L	−14	−100	−10	5.41	lingual
	R	27	−82	−13	4.4	lingual
	R	30	−82	−20	4.82	cerebelum
Social Drinking	L	24	−69	−19	6.09	cerebelum
	R	21	−30	−12	4.02	parahippocampus
	L	−21	−95	−10	5.56	lingual
	R	18	−93	−6	7.68	occipital

Table 2.