Skip to main content
Netherlands Heart Journal logoLink to Netherlands Heart Journal
. 2001 Dec;9(9):383–385.

Essential thrombocythaemia as cause of myocardial infarction

A Derks, MH Bloemer
PMCID: PMC2504434  PMID: 25696769

Abstract

Abnormalities in the number and function of platelets may contribute to thromboembolic complications in patients with essential thrombocythaemia (ET). Rarely this can lead to an acute myocardial ischaemic syndrome. We describe a young patient with a myocardial infarction, in whom ET was found as the probable cause. We discuss the clinical presentation of ET and the therapeutic possibilities.

Keywords: essential thrombocythaenia, myocardial infarction, treatment

Full text

PDF
383

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbui T., Cortelazzo S., Viero P., Bassan R., Dini E., Semeraro N. Thrombohaemorrhagic complications in 101 cases of myeloproliferative disorders: relationship to platelet number and function. Eur J Cancer Clin Oncol. 1983 Nov;19(11):1593–1599. doi: 10.1016/0277-5379(83)90091-3. [DOI] [PubMed] [Google Scholar]
  2. Barr I., Cohen P., Berken A., Lown B. Thrombocythemia and myocardial ischemia with normal coronary angiogram. Arch Intern Med. 1974 Sep;134(3):528–533. [PubMed] [Google Scholar]
  3. Cortelazzo S., Finazzi G., Ruggeri M., Vestri O., Galli M., Rodeghiero F., Barbui T. Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. N Engl J Med. 1995 Apr 27;332(17):1132–1136. doi: 10.1056/NEJM199504273321704. [DOI] [PubMed] [Google Scholar]
  4. Douste-Blazy P., Taudou M. J., Delay M., Pris J., Sie P., Ribaut L., Galinier F., Bernadet P. Essential thrombocythaemia and recurrent myocardial infarction. Lancet. 1984 Oct 27;2(8409):992–992. doi: 10.1016/s0140-6736(84)91217-0. [DOI] [PubMed] [Google Scholar]
  5. Louwerenburg J. W., Suttorp M. J., Herie Kingma J. Aspirin withdrawal in a patient with essential thrombocythemia: possible cause of myocardial infarction. Am J Med. 1987 Dec;83(6):1175–1175. doi: 10.1016/0002-9343(87)90973-9. [DOI] [PubMed] [Google Scholar]
  6. McIntyre K. J., Hoagland H. C., Silverstein M. N., Petitt R. M. Essential thrombocythemia in young adults. Mayo Clin Proc. 1991 Feb;66(2):149–154. doi: 10.1016/s0025-6196(12)60486-8. [DOI] [PubMed] [Google Scholar]
  7. Michaels A. D., Whisenant B., MacGregor J. S. Multivessel coronary thrombosis treated with abciximab (ReoPro) in a patient with essential thrombocythemia. Clin Cardiol. 1998 Feb;21(2):134–138. doi: 10.1002/clc.4960210218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Michiels J. J., Kutti J., Stark P., Bazzan M., Gugliotta L., Marchioli R., Griesshammer M., van Genderen P. J., Brière J., Kiladjian J. J. Diagnosis, pathogenesis and treatment of the myeloproliferative disorders essential thrombocythemia, polycythemia vera and essential megakaryocytic granulocytic metaplasia and myelofibrosis. Neth J Med. 1999 Feb;54(2):46–62. doi: 10.1016/s0300-2977(98)00143-0. [DOI] [PubMed] [Google Scholar]
  9. Momiyama T., Hiranaka T., Nomura F., Tominaga H., Nishioka T. Coronary artery bypass grafting for left main trunk coronary artery lesion associated with essential thrombocythemia. Clin Cardiol. 1993 Sep;16(9):691–693. doi: 10.1002/clc.4960160912. [DOI] [PubMed] [Google Scholar]
  10. Okayasu N., Murata M., Ueda A., Su K. M., Sada T., Ito T., Hasegawa Y., Matsumoto S., Ito Y. Primary thrombocythemia and myocardial infarction in a 26-year-old woman with normal coronary arteriogram. Jpn Heart J. 1981 May;22(3):439–445. doi: 10.1536/ihj.22.439. [DOI] [PubMed] [Google Scholar]
  11. Pick R. A., Glover M. U., Nanfro J. J., Dubbs W. F., Gibbons J. A., Vieweg W. V. Acute myocardial infarction with essential thrombocythemia in a young man. Am Heart J. 1983 Aug;106(2):406–407. doi: 10.1016/0002-8703(83)90213-2. [DOI] [PubMed] [Google Scholar]
  12. Regev A., Stark P., Blickstein D., Lahav M. Thrombotic complications in essential thrombocythemia with relatively low platelet counts. Am J Hematol. 1997 Nov;56(3):168–172. doi: 10.1002/(sici)1096-8652(199711)56:3<168::aid-ajh6>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  13. SPACH M. S., HOWELL D. A., HARRIS J. S. Myocardial infarction and multiple thromboses in a child with primary thrombocytosis. Pediatrics. 1963 Feb;31:268–276. [PubMed] [Google Scholar]
  14. Saffitz J. E., Phillips E. R., Temesy-Armos P. N., Roberts W. C. Thrombocytosis and fatal coronary heart disease. Am J Cardiol. 1983 Sep 1;52(5):651–652. doi: 10.1016/0002-9149(83)90050-4. [DOI] [PubMed] [Google Scholar]
  15. Venegoni P., Schroth G. Myocardial infarction and polycythemia vera: how should we treat it? Cathet Cardiovasc Diagn. 1994 Jul;32(3):259–261. doi: 10.1002/ccd.1810320313. [DOI] [PubMed] [Google Scholar]
  16. Virmani R., Popovsky M. A., Roberts W. C. Thrombocytosis, coronary thrombosis and acute myocardial infarction. Am J Med. 1979 Sep;67(3):498–506. doi: 10.1016/0002-9343(79)90800-3. [DOI] [PubMed] [Google Scholar]
  17. van Genderen P. J., Michiels J. J. Primary thrombocythemia: diagnosis, clinical manifestations and management. Ann Hematol. 1993 Aug;67(2):57–62. doi: 10.1007/BF01788127. [DOI] [PubMed] [Google Scholar]

Articles from Netherlands Heart Journal are provided here courtesy of Springer

RESOURCES