Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Evidence for the requirement of OR internalization in the opioid activation of ERK in HEK-293 cells. Cells cotransfected with δ-, μ-, or κ-OR, DWT, or mutant K44A were treated with 1 μm DPDPE (A), 0.1 μm DADLE (B), 1 μmDAMGE (C), or 1 μm U69,593 (D) for different time intervals.Top, Representative autoradiograms showing the phosphorylated MBP bands. Bottom, Quantification of ERK activity. n = 2–6; *p < 0.05.
