Figure 1.

Effect of linopirdine on ACh-evoked responses in outer hair cells. Cells (P21–27) were voltage-clamped at −30 mV. Shown are representative traces (n = 3) of the responses to 100 μM ACh either alone or in the presence of 100 μM linopirdine. Holding current was −17.5 pA. Each dashed line indicates the zero-current level. Linopirdine was coapplied with ACh or, where indicated, preincubated for 5 min prior to the application of the agonist. During the preincubation with linopirdine, the holding current changed to −34.5 pA.