TABLE 2.

Dose–response relationships of candidate ototoxic drugs represented as hair cell survival after treatment with increasing doses of each drug

Drug	Hair cell survival (% of control)					ANOVA
	0 μM	50 μM	100 μM	200 μM	400 μM
Candesartan	100 ± 11	90 ± 9	82 ± 9	67 ± 13	Dead	p < 0.0001
Chloramphenicol	100 ± 15	42 ± 18	19 ± 7	19 ± 10	10 ± 11	p < 0.0001
Chlorophyllide	100 ± 18	92 ± 7	47 ± 8	24 ± 15	7 ± 6	p < 0.0001
Chlortetracycline	100 ± 15	101 ± 10	79 ± 24	63 ± 21	43 ± 16	p < 0.0001
Cisplatin	100 ± 12	93 ± 12	94 ± 10	95 ± 12	88 ± 13	p = 0.22
Demeclocycline	100 ± 12	101 ± 14	98 ± 13	92 ± 8	93 ± 9	p = 0.21
Estradiol valerate	100 ± 16	60 ± 16	56 ± 14	46 ± 16	Dead	p < 0.0001
Ethacrynic acid	100 ± 8	70 ± 17	52 ± 17	44 ± 12	Dead	p < 0.0001
Guaiazulene	100 ± 11	83 ± 13	54 ± 9	52 ± 15	Dead	p < 0.0001
Kanamycin	100 ± 17	98 ± 14	86 ± 15	84 ± 10	85 ± 6	p < 0.05
Mefloquine	100 ± 13	91 ± 14	81 ± 19	76 ± 17	Dead	p < 0.01
Neomycin	100 ± 14	74 ± 8	43 ± 9	18 ± 4	4 ± 4	p < 0.0001
Pentamidine	100 ± 6	68 ± 9	57 ± 13	54 ± 11	36 ± 10	p < 0.0001
Pentetrazole	100 ± 13	99 ± 14	91 ± 8	89 ± 9	92 ± 14	p = 0.14
Pomiferin	100 ± 15	44 ± 18	45 ± 18	45 ± 18	Dead	p < 0.0001
Propantheline	100 ± 12	68 ± 16	53 ± 16	49 ± 10	18 ± 8	p < 0.0001
Rosolic acid	100 ± 12	83 ± 16	68 ± 14	22 ± 11	23 ± 9	p < 0.0001
Simvastatin	100 ± 9	67 ± 13	48 ± 12	Dead	Dead	P < 0.0001
Spermadine	100 ± 16	61 ± 10	7 ± 6	1 ± 2	1 ± 1	p < 0.0001
Tobramycin	100 ± 12	95 ± 17	53 ± 15	49 ± 10	33 ± 15	P < 0.0001
Vincamine	100 ± 12	69 ± 14	47 ± 15	45 ± 16	13 ± 8	p < 0.0001

Dose dependency was evaluated with one-way ANOVA. Some drug doses were toxic to the fish and are indicated as “Dead.”