FIG. 5.

EP values and DPOAEs were reduced after introducing ESCs into the scala media. A The same animal shown in Fig. 4a. Left panel shows that CAP responses were absent across all frequencies in the treated ear. EP values were reduced about 20–30 mV at turn one, turn two, and turn three compared to the mean EPs from a group of control gerbils (n = 12). Right panel demonstrates that DPOAEs were reduced across all frequencies. Dotted line indicates the noise floor of the system. B An early post-injury cochlea 3 weeks after ESCs were injected into the perilymphatic space. Left panel demonstrates that CAP responses were absent across all frequencies in the treated ear, whereas EP values were relatively normal. Right panel showed that DPOAEs remained similar to control levels in this ear.